General Information

  • ID:  hor006889
  • Uniprot ID:  P04141??19-144)
  • Protein name:  Granulocyte-macrophage colony-stimulating factor
  • Gene name:  LGALS1
  • Organism:  Homo sapiens
  • Family:  GM-CSF family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex; GO:0043231 intracellular membrane-bounded organelle; GO:0005886 plasma membrane
  • GO BP:  GO:0005125 cytokine activity; GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding; GO:0008083 growth factor activity
  • GO CC:  GO:0042045 epithelial fluid transport; GO:0001892 embryonic placenta development; GO:0007259 cell surface receptor signaling pathway via JAK-STAT; GO:0071222 cellular response to lipopolysaccharide; GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus; GO:0008283 cell population proliferation; GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway; GO:0097028 dendritic cell differentiation; GO:0001821 histamine secretion; GO:0045892 negative regulation of DNA-templated transcription; GO:0030225 macrophage differentiation; GO:0034021 response to silicon dioxide; GO:0034405 response to fluid shear stress; GO:0045187 regulation of circadian sleep/wake cycle sleep; GO:0071803 positive regulation of podosome assembly; GO:0010744 positive regulation of macrophage derived foam cell differentiation; GO:0070665 positive regulation of leukocyte proliferation; GO:0006955 immune response; GO:0032747 positive regulation of interleukin-23 p

Sequence Information

  • Sequence:  PARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
  • Length:  126
  • Propeptide:  MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
  • Signal peptide:  MWLQSLLLLGTVACSIS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA